Research:
Health promoting and anti-inflammatory effects of phytochemicals from muscadine grapes, grain sorghum bran, and peanut skins; computer modeling for health education.

Teaching:
FDNS2400, Introduction to Nutrition Research; FDNS3100, Macronutrients and energy balance; FDNS4550/6550, Nutrient Biodynamics.

Outreach:
None

Interests:
Research is done on effects of phytochemicals in muscadine grapes and whole grains on cholesterol, body weight regulation, and metabolic syndrome. Nutraceuticals, gene expression, and nutritional bioinformatics in relation to patent development are current concerns.

Education:

Selected Publications/Presentations:

Books Hartle DK, Greenspan P and Hargrove J (2008) Muscadine Health, Lulu Press, NC; Berdanier, C.D., and Hargrove, J.L. (1993) editors, Nutrition and Gene Expression, CRC Press, Boca Raton, FL , 579 pp. Hargrove, J.L. Kinetic Modeling of Gene Expression, (1994) R. G. Landes Co., Austin Tx, 92 pp. Hargrove, J.L. (1998) Dynamic Modeling in the Health Sciences, New York, Springer Verlag, 298 pp. Includes a CD-ROM diskette with 40 computer simulation models and Run-Time STELLA 5.0 software. Samples of Journal Publications Hargrove JL, Hartle DK and Greenspan P. Nutritional significance and metabolism of very long chain fatty alcohols and acids from dietary waxes. Experimental Biol. Med. (Maywood). 2004 Mar;229 (3):215-26. Zhang F, Yu W, Hargrove JL, Greenspan P, Dean RG, Taylor EW, Hartle DK. (2002) Inhibition of TNF-alpha induced ICAM-1, VCAM-1 and E-selectin expression by selenium. Atherosclerosis. 2002 Apr;161(2):381-386 Hargrove, J. L., Hulsey, M. G., Schmidt, F. H., and Beale, E. G. (1990) A computer program for modeling the kinetics of gene expression. BioTechniques 8:654-659. Hargrove, J.L., Hulsey. M., and Beale, E.G. (1991) The kinetics of mammalian gene expression BioEssays 13, 667-674. Hargrove, J. L. and Schmidt, F. H. (1989) The role of messenger RNA and protein stability in gene expression. FASEB J. 3: 2360-2370.